Please join Ascendia on June 24th for a Live Webcast
Register today to watch Ascendia’s webinar entitled "Overviews of Lyophilization Process Steps and Mechanisms for Biological Molecule Stabilization during Freezing, Drying and Storage".
The webinar will discuss main steps in the lyophilization process and how proteins behave during these steps; mechanisms for protein stabilization by excipients during freezing, drying, storage, and reconstitution; and minimal physical criteria for assuring long-term stability of lyophilized protein formulations
Our presenters are Shaukat Ali, PhD, Senior Director of Scientific Affairs and Technical Marketing of Ascendia and John Carpenter, PhD, professor emeritus of pharmaceutical sciences at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, and a cofounder and codirector of the University of Colorado Center for Pharmaceutical Biotechnology.
Event Overview:
In the first 10 minutes, Ascendia Pharmaceuticals will present its expertise and capabilities in nanoparticle technologies. In the following 40 minutes this webinar will be focused on lyophilized formulations of biological molecules (eg, proteins). This presentation will examine the main steps in the lyophilization process and the mechanisms by which excipients provide stabilization to protein during freezing, drying, storage, and reconstitution.
The key physical factors governing long-term stability also will be discussed. During freezing, effective excipients (eg, sucrose or trehalose) stabilize proteins by the preferential exclusion mechanism. During drying the stabilizer molecules replace water molecules removed from the surface of the protein (water replacement mechanism). Surfactants can stabilize the protein during freezing and minimize aggregation during reconstitution. For long-term storage stability, minimal criteria include retention of native protein structure during freezing and drying; a formulation glass transition temperature well above the planned storage temperature; and relatively low residual water content (eg, 1%).
Key Learning Objectives:
In this webinar you’ll learn:
- Ascendia’s expertise and capabilities
- The main steps in the lyophilization process and how proteins behave during these steps
- The mechanisms for protein stabilization by excipients during freezing, drying, storage, and reconstitution
- The minimal physical criteria for assuring long-term stability of lyophilized protein formulations
Who Should Attend:
- Formulation scientists in industry
- Analytical chemists in industry
- University students and professors
- Managers, VPs, chief scientific officers, pharma consultants, and regulatory scientists